The San Francisco 49ers enjoyed one week with an offense near full health for the first time since Week 1 but they once again appear to be without multiple key contributors.
Brock Purdy’s status for today has been determined. Speculation has run rampant about the quarterback’s toe and shoulder injuries that he suffered back in Week 1.
San Francisco comes into Week 5 with a 3-1 record, tied with the Rams and Seahawks in the NFC West. They are battling to stay atop the division race which is an important factor in the decision regarding Purdy today. With a division battle on deck for the 49ers on “Thursday Night Football,” Niners fans are hopeful their starting signal-caller will be under center.
The 49ers have been battered by injuries; they have experience playing without their top players already. Here’s the latest on Purdy before Thursday’s kickoff at SoFi Stadium against the Rams.
Brock Purdy injury update
The 49ers have ruled out their starting quarterback for today’s game.
The team delivered the discouraging news about Purdy’s status on Wednesday afternoon.
Purdy has been a weekly staple on the injury report since Week 1, when he suffered the initial toe and shoulder injuries and tonight will mark his third missed game already in 2025. He suited up in Week 4 against the Jacksonville Jaguars and played the entire game but the alarms began to sound in the lead-up to tonight’s game when coach Kyle Shanahan shared on Monday that Purdy was sore.
Purdy then failed to participate in practice on Tuesday and Wednesday before the 49ers ruled him out.
San Francisco has been no stranger to playing without its stars on offense this season. Brandon Aiyuk remains out as he works his way back from a torn ACL he suffered in Week 7 last season. All-Pro tight end George Kittle has been sidelined since suffering a hamstring injury in Week 1.
Wide receivers Ricky Pearsall and Jauan Jennings are also set to miss tonight’s game. It will be the second game missed for Jennings and the first for Pearsall in 2025.
Mac Jones will start in place of Purdy for the third time this season, having previously started in Weeks 2 and 3. The 49ers have won both games with Jones as the starter, achieving a 26-21 victory over the New Orleans Saints on the road and a 16-15 win against the Arizona Cardinals at home.
49ers QB depth chart
San Francisco’s depth on offense has been tested all season. Here’s a look at how the quarterback room breaks down with Purdy out:
Martinez will likely join the active roster for Thursday’s game against the Rams. Martinez has been promoted from the practice squad in Jones’ previous two starts. Rourke is unlikely to play at all in 2025 while he recovers from his ACL injury.
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