Wales number eight Taulupe Faletau has been ruled out of the rest of the World Cup after suffering a broken arm during their 43-19 win against Georgia.
Faletau was forced off in the second half of Saturday’s victory and after the game head coach Warren Gatland confirmed he was out of the tournament.
Fly-half Gareth Anscombe will be assessed after suffering a groin injury in the warm-up.
Full-back Liam Williams is also an injury concern.
Williams left the stadium on crutches after suffering a knee injury and will be a doubt for next weekend’s quarter-final, but Wales coach Warren Gatland was more cautiously optimistic about the full-back’s fitness.
Gatland confirmed Wales would call up a replacement for Faletau but were waiting to see the extent of Anscombe’s injury.
“Toby [Taulupe] has broken his arm so he’ll be out,” said Gatland.
“We’re just going to assess Gareth over the next 72 hours. He’s pulled his groin very high up. Talking to the medics, he’s got a bit of power still in his leg which is a positive.
“It means he’s not pulled it off the bone. We’ll probably know in the next 48-72 hours what we need to do with him. Whether we’ve got time for him to recover or replace him directly.
“We’ve got to look at a replacement for Faletau, whether that’s directly as a loose-forward replacement or whether we look at another position.”
Wales’ win has set up a last eight in Marseille on Saturday, 14 October, almost certainly against Argentina or Japan.
“We’ve got a few sore players, particularly in the backs, after today’s game,” Gatland added.
“If you see Liam Williams on crutches, it’s not that he’s done anything significantly bad. He got a whack on the knee and the medics, from a comfort perspective, have put him on crutches to save him walking around a bit.
“He’s got a knock and probably won’t take a huge part in training in the early part of next week. But hopefully he’ll be fit for the quarter-final.”
Flanker Aaron Wainwright is expected to slot into the number eight position, with flanker Tommy Reffell in contention to line up in the same back row as co-captain Jac Morgan. Reffell was named player-of-the-match in the win against Georgia.
Anscombe suffered a groin problem in the warm-up that ruled him out of their final Pool C game in Nantes. The fly-half picked up his injury while practicing kicking and left the field in distress.
Sam Costelow replaced Anscombe in the starting XV, with Dan Biggar coming onto the replacements’ bench.
Biggar himself was not initially selected for the Georgia game after suffering a pectoral injury against Australia.
Anscombe had replaced Biggar in the early stages of the win over the Wallabies 13 days ago and produced a man-of-the-match performance by kicking 23 points.
