A win for USA, currently second in this group with four points, will put an end to the World Cup campaign of Pakistan, who have two points from three matches.
Of course, it will also take the co-hosts into the Super Eight from this group along with India.
Ireland are a competitive side with experienced players in their ranks, but they look woefully out of sync here and the task might be heavier against the US, who are playing some very good T20 cricket at the moment.
They will be keeping an eye on the fitness of skipper Monank Patel, who missed the match against India on Wednesday with a left-shoulder injury.
Aaron Jones did the duty of skipper against Rohit Sharma’s men in New York.
There is also a strong rain threat to the match as per weather predictions, and even a washout can end the campaign of Pakistan.
It will take the USA to five points and beyond the reach of Pakistan, who can now log a maximum of four points.
Teams (from)
Ireland: Paul Stirling (c), Mark Adair, Ross Adair, Andrew Balbirnie, Curtis Campher, Gareth Delany, George Dockrell, Graham Hume, Josh Little, Barry McCarthy, Neil Rock, Harry Tector, Lorcan Tucker, Ben White, Craig Young.
USA: Monank Patel (c), Aaron Jones, Andries Gous, Corey Anderson, Ali Khan, Harmeet Singh, Jessy Singh, Milind Kumar, Nisarg Patel, Nitish Kumar, Noshtush Kenjige, Saurabh Nethralvakar, Shadley Van Schalkwyk, Steven Taylor, Shayan Jahangir . Reserve Players: Gajanand Singh, Juanoy Drysdale, Yasir Mohammad.