Barcelona leads Madrid by four points and a victory would give it a comfortable cushion, but a Madrid win would throw open the title chase in the three remaining rounds.
Barcelona is seeking a double after having beaten Madrid 3-2 in extra time in the Copa del Rey final two weeks ago. A Barcelona triumph would also complete a sweep of all four clasicos this season; it beat Madrid 5-2 in the Spanish Super Cup in January after winning 4-0 at Madrid in the league in October.
Madrid, in contrast, is trying to salvage a disappointing season by successfully defending its La Liga title ahead of this summer’s expanded Club World Cup.